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ML198
CAS No. 1380716-06-2
ML198( —— )
Catalog No. M23537 CAS No. 1380716-06-2
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
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| 2MG | 39 | In Stock |
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| 5MG | 84 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 255 | In Stock |
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| 50MG | 373 | In Stock |
|
| 100MG | 554 | In Stock |
|
| 200MG | 733 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML198
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NoteResearch use only, not for human use.
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Brief DescriptionML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase.
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DescriptionML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.
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In VitroML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr.ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 μM, compared to 5% of DMSO) in human fibroblasts.ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGlucokinase
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Recptorglucocerebrosidase
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Research Area——
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Indication——
Chemical Information
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CAS Number1380716-06-2
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Formula Weight290.32
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Molecular FormulaC17H14N4O
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Purity>98% (HPLC)
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SolubilityDMSO:Insoluble;Water:Insoluble
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SMILESCC1=CC(=NC2=C(C=NN12)C(=O)NC3=CC=C(C=C3)C#C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rogers S , Patnaik S , Schoenen F , et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase[M]. PubMed, 2010.
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