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ZL-006
CAS No. 1181226-02-7
ZL-006( ZL 006 | ZL006 )
Catalog No. M10618 CAS No. 1181226-02-7
ZL-006 (ZL 006, ZL006) is a brain penetrant small molecule inhibitor of PSD-95/nNOS interaction that prevents glutamate-induced excitotoxicity and cerebral ischemic damage in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 91 | In Stock |
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| 25MG | 178 | In Stock |
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| 50MG | 284 | In Stock |
|
| 100MG | 485 | In Stock |
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| 200MG | 700 | In Stock |
|
| 500MG | 1062 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameZL-006
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NoteResearch use only, not for human use.
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Brief DescriptionZL-006 (ZL 006, ZL006) is a brain penetrant small molecule inhibitor of PSD-95/nNOS interaction that prevents glutamate-induced excitotoxicity and cerebral ischemic damage in vivo.
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DescriptionZL-006 (ZL 006, ZL006) is a brain penetrant small molecule inhibitor of PSD-95/nNOS interaction that prevents glutamate-induced excitotoxicity and cerebral ischemic damage in vivo; selectively blocks the ischemia-induced nNOS-PSD-95 association, shows potent neuroprotective activity in vitro and ameliorates focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusio; does not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and has no effect on aggressive behaviors.
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In VitroZL006 presents little cytotoxicity, and a growth inhibition of BCECs is not found at low concentration of 0.001, 0.01, 0.1, 1 and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is significantly enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs. ZL006 does not inhibit the nNOS-PDZ/PSD-95-PDZ interaction, or perturb the nNOS β-finger.
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In VivoCompared with P-LPs/ZL006 and free ZL006, T7-P-LPs/ZL006 exhibits a significant increase of drug accumulation in the brain tissue due to its better brain targeting delivery. Compared with free ZL006, P-LPs/ZL006 and T7-P-LPs/ZL006 exhibit a significant decrease of drug accumulation in the liver and kidney.
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SynonymsZL 006 | ZL006
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PathwayImmunology/Inflammation
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TargetNOS
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RecptorNOS
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1181226-02-7
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Formula Weight328.1474
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Molecular FormulaC14H11Cl2NO4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 29 mg/mL
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SMILESO=C(O)C1=CC=C(NCC2=CC(Cl)=CC(Cl)=C2O)C=C1O
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Chemical NameBenzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhou L, et al. Nat Med. 2010 Dec;16(12):1439-43.
2. Doucet MV, et al. Neuropsychopharmacology. 2013 Jul;38(8):1575-84.
3. Bach A, et al. Sci Rep. 2015 Jul 16;5:12157.
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