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Lanperisone

CAS No. 116287-14-0

Lanperisone( NK 433 )

Catalog No. M10560 CAS No. 116287-14-0

Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lanperisone
  • Note
    Research use only, not for human use.
  • Brief Description
    Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.
  • Description
    Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion; shows potent and selective activity against K-rasG12D MEFs with IC50 of 4 uM in the CTG viability assay; causes a large population of cells with sub-2N DNA content, induces oxidative stress, but not in wild-type MEFs; suppresses the growth of K-ras-driven tumors without overt toxicity in mice; orally bioactive.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NK 433
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116287-14-0
  • Formula Weight
    285.305
  • Molecular Formula
    C15H18F3NO
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(C(F)(F)F)C=C1)[C@H](C)CN2CCCC2
  • Chemical Name
    (2R)-2-methyl-3-pyrrolidin-1-yl-1-[4-(trifluoromethyl)phenyl]propan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shaw AT, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8. 2. Sakitama K, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):175-87. 3. Glasauer A, et al. Biochem Pharmacol. 2014 Nov 1;92(1):90-101.
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