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ML 604440
CAS No. 1140517-08-3
ML 604440( ML604440 | ML-604440 )
Catalog No. M10493 CAS No. 1140517-08-3
ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 301 | In Stock |
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| 2MG | 161 | In Stock |
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| 5MG | 274 | In Stock |
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| 10MG | 432 | In Stock |
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| 25MG | 715 | In Stock |
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| 50MG | 986 | In Stock |
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| 100MG | 1330 | In Stock |
|
| 200MG | 1786 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML 604440
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NoteResearch use only, not for human use.
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Brief DescriptionML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.
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DescriptionML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor; reduces the cleavage of Ac-PAL-AMC by proteasomes from WT mice in a dose-dependent manner (12.5-200 nM), with no affect on β5/LMP7.
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In Vitro——
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In VivoAnimal Model:Male C57BL/6J mice (6-8-wks old) injected with anti-platelet monoclonal antibody Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg; once daily; 7 days Result:Inhibited LMP2 in vivo.Showed no significant improvement in platelet counts in mice immunized by monoclonal rat anti-mouse CD41 platelet antibody.
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SynonymsML604440 | ML-604440
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number1140517-08-3
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Formula Weight388.194
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Molecular FormulaC17H24BF3N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (257.61 mM)
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SMILESCC(C)C[C@@H](B(O)O)NC(C(NC(C1=CC=CC=C1C(F)(F)F)=O)(C)C)=O
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Chemical Name(R)-(3-methyl-1-(2-methyl-2-(2-(trifluoromethyl)benzamido)propanamido)butyl)boronic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.
2. Basler M, et al. J Immunol. 2012 Aug 15;189(4):1868-77.
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