ML 604440( ML604440 | ML-604440 )

Catalog No. M10493 CAS No. 1140517-08-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML 604440
Note

Research use only, not for human use.
Brief Description

ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.
Description

ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor; reduces the cleavage of Ac-PAL-AMC by proteasomes from WT mice in a dose-dependent manner (12.5-200 nM), with no affect on β5/LMP7.
In Vitro

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In Vivo

Animal Model:Male C57BL/6J mice (6-8-wks old) injected with anti-platelet monoclonal antibody Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg; once daily; 7 days Result:Inhibited LMP2 in vivo.Showed no significant improvement in platelet counts in mice immunized by monoclonal rat anti-mouse CD41 platelet antibody.
Synonyms

ML604440 | ML-604440
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

Proteasome
Research Area

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Indication

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CAS Number

1140517-08-3
Formula Weight

388.194
Molecular Formula

C17H24BF3N2O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (257.61 mM)
SMILES

CC(C)C[C@@H](B(O)O)NC(C(NC(C1=CC=CC=C1C(F)(F)F)=O)(C)C)=O
Chemical Name

(R)-(3-methyl-1-(2-methyl-2-(2-(trifluoromethyl)benzamido)propanamido)butyl)boronic acid

1. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. 2. Basler M, et al. J Immunol. 2012 Aug 15;189(4):1868-77.

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