ALW-II-49-7( DDR2-IN-1 )

Catalog No. M10472 CAS No. 1135219-23-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ALW-II-49-7
Note

Research use only, not for human use.
Brief Description

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM.
Description

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.
In Vitro

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In Vivo

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Synonyms

DDR2-IN-1
Pathway

Tyrosine Kinase
Target

DDR
Recptor

DDR
Research Area

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Indication

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CAS Number

1135219-23-6
Formula Weight

414.388
Molecular Formula

C21H17F3N4O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (241.32 mM)
SMILES

O=C(N)C1=CN=CC(NC2=CC(C(NC3=CC=CC(C(F)(F)F)=C3)=O)=CC=C2C)=C1
Chemical Name

5-((2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)nicotinamide

1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96. 2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

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