Cart
sales@molnova.com
ALW-II-49-7
CAS No. 1135219-23-6
ALW-II-49-7( DDR2-IN-1 )
Catalog No. M10472 CAS No. 1135219-23-6
ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 177 | In Stock |
|
| 5MG | 161 | In Stock |
|
| 10MG | 242 | In Stock |
|
| 25MG | 440 | In Stock |
|
| 50MG | 634 | In Stock |
|
| 100MG | 901 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1814 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameALW-II-49-7
-
NoteResearch use only, not for human use.
-
Brief DescriptionALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM.
-
DescriptionALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.
-
In Vitro——
-
In Vivo——
-
SynonymsDDR2-IN-1
-
PathwayTyrosine Kinase
-
TargetDDR
-
RecptorDDR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1135219-23-6
-
Formula Weight414.388
-
Molecular FormulaC21H17F3N4O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (241.32 mM)
-
SMILESO=C(N)C1=CN=CC(NC2=CC(C(NC3=CC=CC(C(F)(F)F)=C3)=O)=CC=C2C)=C1
-
Chemical Name5-((2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)nicotinamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.
2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
molnova catalog
related products
-
DDR1 inhibitor 7rh
DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8 nM in cell-free kinase assays.
-
DDR-TRK-1
DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM.
-
WRG-28
WRG-28 (DDR2 inhibitor WRG-28) is a potent, selective, allosteric inhibitor of discoidin domain receptor 2 (DDR2) with binding IC50 of 230 nM.
