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Linopirdine dihydrochloride
CAS No. 113168-57-3
Linopirdine dihydrochloride( DUP-996 dihydrochloride )
Catalog No. M10459 CAS No. 113168-57-3
Linopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLinopirdine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLinopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
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DescriptionLinopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.Alzheimer Disease Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsDUP-996 dihydrochloride
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number113168-57-3
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Formula Weight464.39
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Molecular FormulaC26H21N3O.2HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5.[H]Cl.[H]Cl
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Chemical Name1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.
2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.
3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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