IM-12( IM 12 | IM12 )

Catalog No. M10456 CAS No. 1129669-05-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

IM-12
Note

Research use only, not for human use.
Brief Description

IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
Description

IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling; attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.
In Vitro

IM-12 inhibits GSK-3β in ReNcell VM cells, with I50 of 3.8 μM. IM-12 (3 μM) enhances the β-catenin amount, with no further effect at lower or higher concentration. IM-12 (3 μM) also attenuates the proliferation of ReNCell VM cells. IM-12 increases TCF-activity of ReNcell VM.
In Vivo

——
Synonyms

IM 12 | IM12
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3β
Research Area

Other Indications
Indication

——

CAS Number

1129669-05-1
Formula Weight

377.4115
Molecular Formula

C22H20FN3O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 54.9 mg/mL
SMILES

FC(C=C1)=CC=C1CCNC(C2=O)=C(C(N2C)=O)C(C3=C(C=CC=C3)N4)=C4C
Chemical Name

1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-

1. Schm?le AC, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

Calculator

molnova catalog