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TR-100
CAS No. 1128165-86-5
TR-100( TR100 | TR 100 )
Catalog No. M10450 CAS No. 1128165-86-5
TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTR-100
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NoteResearch use only, not for human use.
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Brief DescriptionTR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.
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DescriptionTR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models.
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In Vitro——
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In Vivo——
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SynonymsTR100 | TR 100
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorMicrotubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number1128165-86-5
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Formula Weight422.617
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Molecular FormulaC26H38N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NCCCCCCCC)/C(C#N)=C/C1=C(C)N(CCCN(C)C)C2=C1C=CC=C2
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Chemical Name2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stehn JR, et al. Cancer Res. 2013 Aug 15;73(16):5169-82.
2. Bonello TT, et al. Sci Rep. 2016 Jan 25;6:19816.
3. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565.
4. Kee AJ, et al. Sci Rep. 2018 Mar 15;8(1):4604.
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