L-arginine monohydrochloride

CAS No. 1119-34-2

L-arginine monohydrochloride( L-(+)-Arginine | NSC 7914 | NSC 203450 )

Catalog No. M10428 CAS No. 1119-34-2

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1G 43 In Stock

Biological Information

  • Product Name
    L-arginine monohydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
  • Description
    L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.(In Vitro):Arginine is an α-amino acid. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
  • In Vitro
    Arginine is an α-amino acid. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
  • In Vivo
    ——
  • Synonyms
    L-(+)-Arginine | NSC 7914 | NSC 203450
  • Pathway
    Immunology/Inflammation
  • Target
    Amino Acids and Derivatives
  • Recptor
    Amino Acids and Derivatives
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1119-34-2
  • Formula Weight
    210.66
  • Molecular Formula
    C6H15ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    Water: 42 mg/mL (199.37 mM)
  • SMILES
    N[C@@H](CCCNC(N)=N)C(O)=O.[H]Cl
  • Chemical Name
    L-arginine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Morris CR, et al. Am J Respir Crit Care Med, 2003, 168(1), 63-69.
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