L-Selenomethionine

Research use only, not for human use.

L-Selenomethionine is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase glutathione reductase.

L-Selenomethionine is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase glutathione reductase.

L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells.L-Seleno Methionine (500 μM; 48 h) induce apoptosis in prostate cancer cells.L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells.L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation. Cell Viability Assay Cell Line:Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)Concentration:1, 5, 10, 50, 100, 500 μM Incubation Time:24, 48, 72 hours Result:Inhibited the growth of prostate cancer cells, with a lower IC50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).Apoptosis Analysis Cell Line:Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt Concentration:500 μ Incubation Time:48 hours Result:Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.Exhibited the nicked-end DNA labeling in prostate cancer cells.Promoted the PARP cleavage in prostate cancer cells.Cell Cycle Analysis Cell Line:Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)Concentration:500 μM Incubation Time:48 hours Result:Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.RT-PC R Cell Line:Human thyroid epithelial cells (HTori-3) Concentration:5 μM Incubation Time:24 hours Result:Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.

L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.

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Immunology/Inflammation

Amino Acids and Derivatives

Amino Acids and Derivatives

Cancer

Colorectal Cancer

3211-76-5

196.1

C5H11NO2Se

>98% (HPLC)

DMSO: 10 mM;Water: 50 mg/mL (254.96 mM)

C[Se]CC[C@H](N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years