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Efonidipine hydrochloride

CAS No. 111011-53-1

Efonidipine hydrochloride( NZ-105 hydrochloride )

Catalog No. M10408 CAS No. 111011-53-1

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Efonidipine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker.
  • Description
    Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation; increases coronary blood flow by blocking L & T-type calcium channels and attenuates myocardial ischaemia, lowers blood pressure in cerebral resistance vessels and prevents hypertension induced brain damage; increases glomerular filtration rate without increasing intra-glomerular pressure and filtration fraction.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NZ-105 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    111011-53-1
  • Formula Weight
    668.1161
  • Molecular Formula
    C34H39ClN3O7P
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 8.5 mg/mL
  • SMILES
    CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl
  • Chemical Name
    3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Masuda Y, et al. Arch Int Pharmacodyn Ther. 1990 Mar-Apr;304:247-64. 2. Tamura T, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):405-10. 3. Shudo C, et al. Gen Pharmacol. 1994 Nov;25(7):1451-8. 4. Yamashita T, et al. Jpn J Pharmacol. 1991 Nov;57(3):337-48.
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