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Tepotinib
CAS No. 1100598-32-0
Tepotinib( EMD-1214063 | EMD 1214063 | EMD1214063 )
Catalog No. M10385 CAS No. 1100598-32-0
Tepotinib (EMD-1214063) is a potent and highly selective c-Met inhibitor with IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 80 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 224 | In Stock |
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| 50MG | 367 | In Stock |
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| 100MG | 520 | In Stock |
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| 200MG | 752 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTepotinib
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NoteResearch use only, not for human use.
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Brief DescriptionTepotinib (EMD-1214063) is a potent and highly selective c-Met inhibitor with IC50 of 3 nM.
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DescriptionTepotinib (EMD-1214063) is a potent and highly selective c-Met inhibitor with IC50 of 3 nM; shows selectivity versus a panel of 242 human kinases; inhibits c-Met phosphorylation and downstream signaling in a dose-dependent fashion; induces regression of human tumors in murine xenograft models.Liver Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsEMD-1214063 | EMD 1214063 | EMD1214063
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PathwayAngiogenesis
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Targetc-Met/HGFR
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RecptorAXL|c-Met|TrkA
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Research AreaCancer
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IndicationLiver Cancer
Chemical Information
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CAS Number1100598-32-0
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Formula Weight492.5716
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Molecular FormulaC29H28N6O2
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Purity>98% (HPLC)
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SolubilityDMSO: 27 mg/mL
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SMILESN#CC1=CC=CC(C(C=C2)=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C2=O)=C1
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Chemical NameBenzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bladt F, et al. Clin Cancer Res. 2013 Jun 1;19(11):2941-51.
2. Mikami K, et al. Mol Cancer Res. 2015 Dec;13(12):1544-53.
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