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Procaspase-3 activator 1541
CAS No. 1100353-03-4
Procaspase-3 activator 1541( Compound 1541 )
Catalog No. M10383 CAS No. 1100353-03-4
Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 226 | In Stock |
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| 50MG | 355 | In Stock |
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| 100MG | 551 | In Stock |
|
| 200MG | 764 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameProcaspase-3 activator 1541
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NoteResearch use only, not for human use.
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Brief DescriptionProcaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
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DescriptionProcaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM); does not activate procaspases-1 or -7, induces cell death by the fibrillar rather than the soluble form of the compound; induces extensive proteolysis including caspase substrates, yet modulatory profiling reveals that chemi-fibrils form a distinct class from existing inducers of cell death.
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In Vitro——
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In Vivo——
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SynonymsCompound 1541
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase
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Research Area——
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Indication——
Chemical Information
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CAS Number1100353-03-4
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Formula Weight411.417
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Molecular FormulaC24H17N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 1 mg/mL (2.43 mM)
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SMILESO=C(C(C1=O)=CC2=C(O1)C(OC)=CC=C2)NC3=CC=CC(C4=CN5C=CC=CC5=N4)=C3
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Chemical NameN-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.
2. Zorn JA, et al. J Biol Chem. 2012 Sep 28;287(40):33781-95.
3. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.
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