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Procaspase-3 activator 1541

CAS No. 1100353-03-4

Procaspase-3 activator 1541( Compound 1541 )

Catalog No. M10383 CAS No. 1100353-03-4

Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Procaspase-3 activator 1541
  • Note
    Research use only, not for human use.
  • Brief Description
    Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
  • Description
    Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM); does not activate procaspases-1 or -7, induces cell death by the fibrillar rather than the soluble form of the compound; induces extensive proteolysis including caspase substrates, yet modulatory profiling reveals that chemi-fibrils form a distinct class from existing inducers of cell death.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Compound 1541
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1100353-03-4
  • Formula Weight
    411.417
  • Molecular Formula
    C24H17N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 1 mg/mL (2.43 mM)
  • SMILES
    O=C(C(C1=O)=CC2=C(O1)C(OC)=CC=C2)NC3=CC=CC(C4=CN5C=CC=CC5=N4)=C3
  • Chemical Name
    N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76. 2. Zorn JA, et al. J Biol Chem. 2012 Sep 28;287(40):33781-95. 3. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.
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