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ALDH1A inhibitor 673A
CAS No. 109437-62-9
ALDH1A inhibitor 673A( ALDH1Ai 673A )
Catalog No. M10366 CAS No. 109437-62-9
ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameALDH1A inhibitor 673A
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NoteResearch use only, not for human use.
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Brief DescriptionALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor.
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DescriptionALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively; shows no significant activity against ALDH2 (IC50 14 mM) or numerous other ALDH family members; ALDH1Ai 673A preferentially kills CD133+ ovarian cancer stem-like cells (CSCs), induces necroptotic CSC death, mediated, in part, by the induction of mitochondrial uncoupling proteins (UCPs) and reduction in oxidative phosphorylation; ALDH1Ai 673A is highly synergistic with chemotherapy, reducing tumor initiation capacity and increasing tumor eradication in vivo.
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In Vitro——
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In Vivo——
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SynonymsALDH1Ai 673A
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PathwayMetabolic Enzyme/Protease
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TargetALDH
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RecptorALDH
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Research Area——
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Indication——
Chemical Information
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CAS Number109437-62-9
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Formula Weight223.275
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Molecular FormulaC15H13NO
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Purity>98% (HPLC)
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Solubility——
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SMILESC1C2=CC=CC=C2CN1C3=CC=C(C=C3)C=O
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Chemical Name4-(isoindolin-2-yl)benzaldehyde
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chefetz I, et al. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6.
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