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Dexpramipexole

CAS No. 104632-28-2

Dexpramipexole( R)-Pramipexole | KNS-760704 )

Catalog No. M10230 CAS No. 104632-28-2

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Dexpramipexole
  • Note
    Research use only, not for human use.
  • Brief Description
    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.
  • Description
    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Alzheimer's Disease Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    R)-Pramipexole | KNS-760704
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    104632-28-2
  • Formula Weight
    211.3271
  • Molecular Formula
    C10H17N3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCCNC1CCC2=C(C1)SC(=N2)N
  • Chemical Name
    2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alavian KN, et al. Brain Res. 2012 Mar 29;1446:1-11. 2. Cudkowicz M, et al. Nat Med. 2011 Nov 20;17(12):1652-6. 3. Bozik ME, et al. J Clin Pharmacol. 2011 Aug;51(8):1177-85.
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