JTV-519 hydrochloride

Research use only, not for human use.

JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).

JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).Heart Arrhythmia Phase 2 Discontinued.

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Animal Model:Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) Dosage:0.5 mg/kg/h Administration:Applied intraperitoneally 2 h before the surgery Result:Improved cardiac function, where the EF and FS were significantly increased.

K201 | JTV519

GPCR/G Protein

Calcium Channel

Calcium Channel

Cardiovascular Disease

Heart Arrhythmia

1038410-88-6

461.061

C25H33ClN2O2S

>98% (HPLC)

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C1CC(CCN1CCC(=O)N1Cc2c(SCC1)ccc(c2)OC)Cc1ccccc1.Cl

1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hydrochloride

(-20℃)

With Ice Pack

≥ 2 years