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BR111
CAS No. 1037092-93-5
BR111( BR 111 )
Catalog No. M10184 CAS No. 1037092-93-5
BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 ± 40 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBR111
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NoteResearch use only, not for human use.
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Brief DescriptionBR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 ± 40 nM.
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DescriptionBR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 ± 40 nM (inhibition of hC3a induced Ca2+ release on human macrophages); displays high selectivity for C3aR over C5aR; inhibits mast cell degranulation, thereby blocking recruitment and activation of macrophages and neutrophils, expression of inflammatory mediators and inflammation in a rat paw edema model.
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In Vitro——
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In Vivo——
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SynonymsBR 111
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PathwayImmunology/Inflammation
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TargetComplement System
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RecptorComplement System
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Research Area——
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Indication——
Chemical Information
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CAS Number1037092-93-5
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Formula Weight450.557
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Molecular FormulaC24H26N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(5-benzhydrylthiophene-2-carbonyl)-L-arginine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lohman RJ, et al. Nat Commun. 2017 Aug 24;8(1):351.
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