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MK5046

CAS No. 1022152-70-0

MK5046( —— )

Catalog No. M10106 CAS No. 1022152-70-0

MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

MK5046
Note

Research use only, not for human use.
Brief Description

MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity.
Description

MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).
In Vitro

——
In Vivo

Animal Model:Male C57BL/6N mice with high-fat diet for the diet-induced obese (DIO) modelDosage:3, 10 and 30 mg/kg.Administration:Oral administration; 3, 10 and 30 mg/kg for once Result:Dose-dependently inhibited food intake at 2 h and overnight in DIO mice. But showed no effect on Brs3 knockout mice.
Synonyms

——
Pathway

GPCR/G Protein
Target

Bombesin Receptor
Recptor

BRS-3
Research Area

Metabolic Disease
Indication

——

Chemical Information

CAS Number

1022152-70-0
Formula Weight

444.37
Molecular Formula

C20H18F6N4O
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

C1CC1(CC2=CN=C(N2)C[C@](C3=CC=C(C=C3)N4C=CC=N4)(C(F)(F)F)O)C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Guan XM, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364.

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