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Home - Products - Cell Cycle/DNA Damage - Aurora Kinase - MK-5108

MK-5108

CAS No. 1010085-13-8

MK-5108( MK 5108 | VX-689 | VX 689 | MK5108 | VX689 )

Catalog No. M10067 CAS No. 1010085-13-8

MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 78 In Stock
5MG 76 In Stock
10MG 132 In Stock
25MG 227 In Stock
50MG 346 In Stock
100MG 517 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    MK-5108
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM.
  • Description
    MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM, displays robust selectivity against Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assays; also exhibits high selectivity for Aurora-A over a panel of 233 kinases, only one kinase (TrkA) with <100-fold selectivity; inhibits the growth of multiple human cancer cell lines in vitro and in human cancer xenograft models; MK-5108 significantly enhanced the efficacy of docetaxel without increasing its toxicity.Solid Tumors Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MK 5108 | VX-689 | VX 689 | MK5108 | VX689
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    AuroraA
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1010085-13-8
  • Formula Weight
    461.94
  • Molecular Formula
    C22H21ClFN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6.4 mg/mL (Need Warming)
  • SMILES
    OC(=O)[C@@]1(CC2=CC=CC(NC3=NC=CS3)=N2)CC[C@@H](CC1)OC1=C(F)C(Cl)=CC=C1 |r,c:7,13,16,26,30,32,t:5,11|
  • Chemical Name
    Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shimomura T, et al. Mol Cancer Ther. 2010 Jan;9(1):157-66. 2. Kretzner L, et al. Cancer Res. 2011 Jun 1;71(11):3912-20. 3. Shan W, et al. Clin Cancer Res. 2012 Jun 15;18(12):3352-65. 4. Chefetz I, et al. Cell Cycle. 2011 Jul 1;10(13):2206-14.
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