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ML-346

CAS No. 100872-83-1

ML-346( ML346 )

Catalog No. M10056 CAS No. 100872-83-1

A novel activator of HSP70 with EC50 of 4.6 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 73 In Stock
2MG 46 In Stock
5MG 73 In Stock
10MG 111 In Stock
25MG 171 In Stock
50MG 268 In Stock
100MG 419 In Stock
200MG Get Quote In Stock
500MG 918 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ML-346
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel activator of HSP70 with EC50 of 4.6 uM.
  • Description
    A novel activator of HSP70 with EC50 of 4.6 uM; induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models, which are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ML346
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP70
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    100872-83-1
  • Formula Weight
    272.2561
  • Molecular Formula
    C14H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 29 mg/mL
  • SMILES
    O=C(NC(NC/1=O)=O)C1=C\C=C\C2=CC=C(OC)C=C2
  • Chemical Name
    2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Calamini B, et al. Probe Reports from the NIH Molecular Libraries Program.
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