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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - 2',4'-DIHYDROXYCHALCONE

2',4'-DIHYDROXYCHALCONE

CAS No. 1776-30-3

2',4'-DIHYDROXYCHALCONE( 2',4'-DHC )

Catalog No. M22975 CAS No. 1776-30-3

2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effectsIn the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    2',4'-DIHYDROXYCHALCONE
  • Note
    Research use only, not for human use.
  • Brief Description
    2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effectsIn the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.
  • Description
    2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effectsIn the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC. The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced. The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin. Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90. 2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    2',4'-DHC
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP90
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1776-30-3
  • Formula Weight
    240.25
  • Molecular Formula
    C15H12O3?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=C(O)C=C1O)C=CC2=CC=CC=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Seo Y H , Kim S S , Shin K S . In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus[J]. Mycobiology, 2015, 43(2):150-156.
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