Piceatannol

Research use only, not for human use.

Anti-inflammatory, immunomodulatory and antiproliferative agent.

Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol by cytochrome P450 1B1.(In Vitro):Piceatannol is a resveratrol metabolite.SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively.(In Vivo):Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and reduces the infiltration of inflammatory cells induced by lipopolysaccharide.Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced bylipopolysaccharide.Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS.

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Astringenin | trans-Picetannol | trans-3,3',4,5'-Tetrahydroxystilbene

Apoptosis

PKA

cAK| PKC| MLCK

Cancer

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10083-24-6

244.24

C14H12O4

>98% (HPLC)

Ethanol: 48 mg/mL (196.52 mM); DMSO: 48 mg/mL (196.52 mM)

c1(c(ccc(\C=C\c2cc(O)cc(c2)O)c1)O)O

(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol, 3,3′,4,5′-Tetrahydroxy-trans-stilbene

(-20℃)

With Ice Pack

≥ 2 years