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AEM2
CAS No. 1005095-04-4
AEM2( SIRT2 inhibitor AEM2 )
Catalog No. M10039 CAS No. 1005095-04-4
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAEM2
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NoteResearch use only, not for human use.
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Brief DescriptionSIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM.
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DescriptionSIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2; sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide; elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.
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In Vitro——
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In Vivo——
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SynonymsSIRT2 inhibitor AEM2
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin
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Research Area——
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Indication——
Chemical Information
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CAS Number1005095-04-4
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Formula Weight409.533
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Molecular FormulaC27H27N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CC2CC1C3C2C4=C(C=CC(=C4)C(=O)NCC5=CN=CC=C5)NC3C6=CC=CC=C6
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Chemical Name6-phenyl-N-(pyridin-3-ylmethyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.
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