Cart
sales@molnova.com
AEM2
CAS No. 1005095-04-4
AEM2( SIRT2 inhibitor AEM2 )
Catalog No. M10039 CAS No. 1005095-04-4
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAEM2
-
NoteResearch use only, not for human use.
-
Brief DescriptionSIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM.
-
DescriptionSIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2; sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide; elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.
-
In Vitro——
-
In Vivo——
-
SynonymsSIRT2 inhibitor AEM2
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1005095-04-4
-
Formula Weight409.533
-
Molecular FormulaC27H27N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1CC2CC1C3C2C4=C(C=CC(=C4)C(=O)NCC5=CN=CC=C5)NC3C6=CC=CC=C6
-
Chemical Name6-phenyl-N-(pyridin-3-ylmethyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.
molnova catalog
related products
-
WAY-323061
WAY-323061 is a SIRT2 inhibitor.
-
SIRT-IN-1
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
-
SRTCX1003
SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM.
