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Home - Products - Chromatin/Epigenetic - Sirtuin - BPTES

BPTES

CAS No. 314045-39-1

BPTES( BPTES )

Catalog No. M18414 CAS No. 314045-39-1

BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 77 In Stock
2MG 42 In Stock
5MG 60 In Stock
10MG 77 In Stock
25MG 145 In Stock
50MG 213 In Stock
100MG 318 In Stock
200MG 462 In Stock
500MG 756 In Stock
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Biological Information

  • Product Name
    BPTES
  • Note
    Research use only, not for human use.
  • Brief Description
    BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.
  • Description
    BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. BPTES has a K(i) of approx. 3 microM. BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BPTES
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Glutaminase GLS1 (KGA)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    314045-39-1
  • Formula Weight
    524.68
  • Molecular Formula
    C24H24N6O2S3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 95.30 mM;H2O : < 0.1 mg/mL
  • SMILES
    O=C(Cc1ccccc1)Nc1nnc(s1)CCSCCc1sc(nn1)NC(=O)Cc1ccccc1
  • Chemical Name
    N,N'-((thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Le A., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21.
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