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LpxH-IN-AZ1
CAS No. 901260-40-0
LpxH-IN-AZ1( —— )
Catalog No. M32998 CAS No. 901260-40-0
LpxH-IN-AZ1 is a potent inhibitor of the UDP-2,3-diacylglucosamine pyrophosphate hydrolase, LpxH, and sulfonylpiperazine compounds.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 76 | Get Quote |
|
| 5MG | 116 | Get Quote |
|
| 10MG | 183 | Get Quote |
|
| 25MG | 419 | Get Quote |
|
| 50MG | 615 | Get Quote |
|
| 100MG | 858 | Get Quote |
|
| 500MG | 1728 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLpxH-IN-AZ1
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NoteResearch use only, not for human use.
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Brief DescriptionLpxH-IN-AZ1 is a potent inhibitor of the UDP-2,3-diacylglucosamine pyrophosphate hydrolase, LpxH, and sulfonylpiperazine compounds.
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DescriptionLpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .
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In VitroLpxH-IN-AZ1 displays IC50 values of 0.36 μM against K. pneumoniae LpxH and 0.14 μM against E. coli LpxH, respectively. LpxH-IN-AZ1 (1 μM) inhibits 75% of the activity of K. pneumoniae LpxH and 83% of the activity of E. coli LpxH in the presence of 100 μM UDPDAGn.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number901260-40-0
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Formula Weight453.48
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Molecular FormulaC21H22F3N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (55.13 mM; Ultrasonic (<60°C)
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SMILESC(C)(=O)N1C=2C(=CC(S(=O)(=O)N3CCN(CC3)C4=CC(C(F)(F)F)=CC=C4)=CC2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.?
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