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Home - Products - GPCR/G Protein - Antibacterial - SQ609

SQ609

CAS No. 627052-25-9

SQ609( —— )

Catalog No. M35027 CAS No. 627052-25-9

SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SQ609
  • Note
    Research use only, not for human use.
  • Brief Description
    SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives.
  • Description
    SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .
  • In Vitro
    In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells.
  • In Vivo
    SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days.Animal Model:TB susceptible mice (C3H/He)Dosage:10 mg/kg Administration:I.v.Result:Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    627052-25-9
  • Formula Weight
    346.55
  • Molecular Formula
    C22H38N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.67 mg/mL (19.25 mM; Ultrasonic (<60°C)
  • SMILES
    OC1CCN(CC2CCN(CC34CC5CC(CC(C5)C3)C4)CC2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.?
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