Cart
sales@molnova.com
Lats-IN-1
CAS No. 1424635-83-5
Lats-IN-1( —— )
Catalog No. M23576 CAS No. 1424635-83-5
Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 133 | In Stock |
|
| 10MG | 209 | In Stock |
|
| 25MG | 415 | In Stock |
|
| 50MG | 536 | In Stock |
|
| 100MG | 763 | In Stock |
|
| 200MG | 1053 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLats-IN-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionLats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
-
DescriptionLats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
-
In VitroCell Proliferation Assay Cell Line:MCF 10A cells Concentration:10 μM Incubation Time:24 hours Result:Decreased the phosphorylation of Yap at residue S127.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorLats1|Lats2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1424635-83-5
-
Formula Weight334.39
-
Molecular FormulaC18H14N4OS
-
Purity>98% (HPLC)
-
SolubilityDMSO:83.33 mg/mL (249.20 mM; Need ultrasonic)
-
SMILESO=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.
molnova catalog
related products
-
Lecimibide
Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.
-
[Trp7,β-Ala8]-Neurok...
[Trp7,β-Ala8]-Neurokinin A (4-10)
-
Genistein 7,4-di-O-b...
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
