LXW7

Research use only, not for human use.

LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-peptide (cGRGDdvc) containing unnatural amino acids flanking both sides of the main functional motif.

LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-peptide (cGRGDdvc) containing unnatural amino acids flanking both sides of the main functional motif.

LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells.LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery. LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand.

LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines. Animal Model:Male Sprague-Dawley rats (250-280 g) subjected to middle cerebral artery occlusion (MCAO)Dosage:100 μg/kg Administration:Intravenous injection Result:Infarct volumes and BWC were significantly lower compared to those in the MCAO+PBS (control) group.

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Cell Cycle/DNA Damage

Integrin

αVβ3 integrin

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1313004-77-1

820.89

C29H48N12O12S2

>98% (HPLC)

H2O

NC(=O)[C@H]1CSSC[C@@H](N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](C(C)C)C(=O)N1

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(-20℃)

With Ice Pack

≥ 2 years