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LTURM34
CAS No. 1879887-96-3
LTURM34( —— )
Catalog No. M22131 CAS No. 1879887-96-3
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
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| 10MG | 102 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 385 | In Stock |
|
| 100MG | 575 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLTURM34
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NoteResearch use only, not for human use.
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Brief DescriptionLTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines.
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DescriptionLTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .
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In VitroLTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorDNA-PK|PI3Kβ|PI4Kδ
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Research Area——
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Indication——
Chemical Information
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CAS Number1879887-96-3
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Formula Weight414.48
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Molecular FormulaC24H18N2O3S
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Purity>98% (HPLC)
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SolubilityDMSO:60 mg/mL (144.76 mM)
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SMILESO=c1nc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.
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