Cart
sales@molnova.com
KS100
CAS No. 2408477-54-1
KS100( —— )
Catalog No. M35757 CAS No. 2408477-54-1
KS100 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activities.KS100 inhibits ALDH1A1, ALDH2 and ALDH3A1 with IC50 of 334, 2137 and 360 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameKS100
-
NoteResearch use only, not for human use.
-
Brief DescriptionKS100 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activities.KS100 inhibits ALDH1A1, ALDH2 and ALDH3A1 with IC50 of 334, 2137 and 360 nM, respectively.
-
DescriptionKS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.
-
In VitroKS100 (compound 3j) (0-100 μM; 72 h) shows anti-proliferative activity with IC50s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 μM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively.KS100 (5 μM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase.Apoptosis Analysis Cell Line:HCT116, HT29 cells Concentration:5 μM Incubation Time:24 h Result:Induced cell apoptosis.Apoptosis Analysis Cell Line:HCT116 cells Concentration:5 μM Incubation Time:24 hResult:Induced cell cycle arrest at G2/M phase.
-
In Vivo——
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetDehydrogenase
-
RecptorDehydrogenase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2408477-54-1
-
Formula Weight564.09
-
Molecular FormulaC17H14Br3N3O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (221.60 mM; Ultrasonic )
-
SMILESBr.O=C1C(=O)N(C=2C(Br)=CC(Br)=CC12)CC3=CC=C(C=C3)CSC(=N)N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962.?
molnova catalog
related products
-
6PGD-IN-S3
6PGD-IN-S3 is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD).
-
Tiazofurin
Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH) .
-
CAY10566
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
