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KIN101

CAS No. 610753-87-2

KIN101( 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene )

Catalog No. M26270 CAS No. 610753-87-2

KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KIN101
  • Note
    Research use only, not for human use.
  • Brief Description
    KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
  • Description
    KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.(In Vitro):KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.
  • In Vitro
    KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance.KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels.KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells.KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV). Western Blot Analysis Cell Line:MRC5 cells Concentration:10 μM Incubation Time:24 hours Result:Caused a significant decrease in the NP protein abundance. RT-PCR Cell Line:Huh7 cells Concentration:10 μM Incubation Time:18 hours Result:Showed a >1 log decrease in HCV RNA levels.
  • In Vivo
    ——
  • Synonyms
    3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    NMDA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    610753-87-2
  • Formula Weight
    395.22
  • Molecular Formula
    C16H11BrO5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (105.43 mM)
  • SMILES
    CS(=O)(=O)Oc1ccc2c(c1)occ(-c1ccc(Br)cc1)c2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275
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