Cart
sales@molnova.com
Juglone
CAS No. 481-39-0
Juglone( Regianin | 5-Hydroxy-14-naphthoquinone )
Catalog No. M19883 CAS No. 481-39-0
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 86 | In Stock |
|
| 50MG | 122 | In Stock |
|
| 100MG | 170 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameJuglone
-
NoteResearch use only, not for human use.
-
Brief DescriptionJuglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).
-
DescriptionJuglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.
-
In VitroCell Cytotoxicity Assay Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Inhibited cell growth in a dose-dependent manner.Apoptosis Analysis Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Increased the number of early apoptotic cells.Western Blot Analysis Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Decreased the expression of Bcl-2 and increased the Bax protein.
-
In VivoAnimal Model:High-fat diet rats modelDosage:0.25 or 1 mg/kg Administration:p.o.Result:Regulated the expression of s TNF-α, IL-1β and IL-6.Inhibited the TLR4 expression and NF-kappa activity.
-
SynonymsRegianin | 5-Hydroxy-14-naphthoquinone
-
PathwayCell Cycle/DNA Damage
-
TargetDNA/RNA Synthesis
-
RecptorRNA polymerase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number481-39-0
-
Formula Weight174.15
-
Molecular FormulaC10H6O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: 15 mg/mL;Ethanol: 15 mg/mL
-
SMILESOc1cccc2C(=O)C=CC(=O)c12
-
Chemical Name5-hydroxynaphthalene-14-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hennig L et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28;37(17):5953-60.
molnova catalog
related products
-
Syk Inhibitor II
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
-
dUTP trisodium
dUTP trisodium is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
-
NSAH?
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.A unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affinity, inhibition, and cell toxicity assays.?NSAH binds to hRRM1 with an apparent dissociation constant of 37 μM, and steady-state kinetics reveal a competitive mode of inhibition.?
