Integrin-IN-27( MDK-4976 | Integrin Antagonist 27 | MDK4976 | MDK 4976 )

Catalog No. M15199 CAS No. 593274-97-6

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Product Name

Integrin-IN-27
Note

Research use only, not for human use.
Brief Description

A potent integrin αvβ3 antagonist with IC50 of 18 nM; could be conjugated to paclitaxel for selective delivery to alphavbeta3 positive metastatic cancer cells.
Description

A potent integrin αvβ3 antagonist with IC50 of 18 nM; could be conjugated to paclitaxel for selective delivery to alphavbeta3 positive metastatic cancer cells.
In Vitro

——
In Vivo

——
Synonyms

MDK-4976 | Integrin Antagonist 27 | MDK4976 | MDK 4976
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

Cancer
Indication

——

CAS Number

593274-97-6
Formula Weight

444.4394
Molecular Formula

C24H20N4O5
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(O)C1=CC=CC(N2C(/C=C(C(N3CC(NC4=CC=C(C)C=C4)=O)=O)/NC3=O)=CC=C2)=C1
Chemical Name

Benzoic acid, 3-[2-[[1-[2-[(4-methylphenyl)amino]-2-oxoethyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-1H-pyrrol-1-yl]-

1. Dayam R, et al. J Med Chem. 2006 Jul 27;49(15):4526-34.

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