ITX3

CAS No. 347323-96-0

ITX3( —— )

Catalog No. M33387 CAS No. 347323-96-0

ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 33 In Stock
10MG 62 In Stock
25MG 132 In Stock
50MG 257 In Stock
100MG 353 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    ITX3
  • Note
    Research use only, not for human use.
  • Brief Description
    ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.
  • Description
    ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent.
  • In Vitro
    ITX3 (5, 10, 25, 50 and 100 μM; 24 h) inhibits TrioN signaling.ITX3 (50 μM; 1 h) specifically inhibits TrioN.ITX3 (100 μM; 36 h) inhibits nerve growth factor-induced neurite outgrowth in PC12 cells.ITX3 (1, 10 and 100 μM) represses Rac1 activity and dose-dependently up-regulates the E-cadherin protein level and phospho-p38 signal in Tara-KD cells.Western Blot Analysis Cell Line:TrioN-, GEF337-, Tiam1- and Vav2-expressing HEK293 cell lines Concentration:50 μM Incubation Time:1 hourResult:Decreased TrioN-induced Rac activity.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Rho
  • Recptor
    Rho
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    347323-96-0
  • Formula Weight
    371.45
  • Molecular Formula
    C22H17N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2 mg/mL (5.38 mM; Ultrasonic (<80°C)
  • SMILES
    Cc1cc(\C=c2\sc3nc4ccccc4n3c2=O)c(C)n1-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66.?
molnova catalog
related products
  • CCG-1423

    CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

  • (E/Z)-ZINC09659342

    (E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.

  • NS1643

    NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.