
ITX3
CAS No. 347323-96-0
ITX3( —— )
Catalog No. M33387 CAS No. 347323-96-0
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 33 | In Stock |
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10MG | 62 | In Stock |
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25MG | 132 | In Stock |
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50MG | 257 | In Stock |
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100MG | 353 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameITX3
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NoteResearch use only, not for human use.
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Brief DescriptionITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.
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DescriptionITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent.
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In VitroITX3 (5, 10, 25, 50 and 100 μM; 24 h) inhibits TrioN signaling.ITX3 (50 μM; 1 h) specifically inhibits TrioN.ITX3 (100 μM; 36 h) inhibits nerve growth factor-induced neurite outgrowth in PC12 cells.ITX3 (1, 10 and 100 μM) represses Rac1 activity and dose-dependently up-regulates the E-cadherin protein level and phospho-p38 signal in Tara-KD cells.Western Blot Analysis Cell Line:TrioN-, GEF337-, Tiam1- and Vav2-expressing HEK293 cell lines Concentration:50 μM Incubation Time:1 hourResult:Decreased TrioN-induced Rac activity.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetRho
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RecptorRho
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Research Area——
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Indication——
Chemical Information
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CAS Number347323-96-0
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Formula Weight371.45
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Molecular FormulaC22H17N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 2 mg/mL (5.38 mM; Ultrasonic (<80°C)
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SMILESCc1cc(\C=c2\sc3nc4ccccc4n3c2=O)c(C)n1-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66.?
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