ITX3

Research use only, not for human use.

ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.

ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent.

ITX3 (5, 10, 25, 50 and 100 μM; 24 h) inhibits TrioN signaling.ITX3 (50 μM; 1 h) specifically inhibits TrioN.ITX3 (100 μM; 36 h) inhibits nerve growth factor-induced neurite outgrowth in PC12 cells.ITX3 (1, 10 and 100 μM) represses Rac1 activity and dose-dependently up-regulates the E-cadherin protein level and phospho-p38 signal in Tara-KD cells.Western Blot Analysis Cell Line:TrioN-, GEF337-, Tiam1- and Vav2-expressing HEK293 cell lines Concentration:50 μM Incubation Time:1 hourResult:Decreased TrioN-induced Rac activity.

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Cell Cycle/DNA Damage

Rho

Rho

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347323-96-0

371.45

C22H17N3OS

>98% (HPLC)

In Vitro:?DMSO : 2 mg/mL (5.38 mM; Ultrasonic (<80°C)

Cc1cc(\C=c2\sc3nc4ccccc4n3c2=O)c(C)n1-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years