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IQ3

CAS No. 312538-03-7

IQ3( —— )

Catalog No. M22014 CAS No. 312538-03-7

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IQ3
  • Note
    Research use only, not for human use.
  • Brief Description
    IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively).
  • Description
    IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
  • In Vitro
    IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively.IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3. Cell Viability Assay Cell Line:PBMCs.Concentration:0-80 μM (200 ng/mL LPS).Incubation Time:30 min.Result:Downregulated TNF-α concentration (IC50 = 4.7 μM).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    JNK
  • Recptor
    JNK3|JNK1|JNK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    312538-03-7
  • Formula Weight
    341.32
  • Molecular Formula
    C20H11N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (73.25 mM)
  • SMILES
    O=C(ON=C1C2=CC=CC=C2C2=NC3=CC=CC=C3N=C12)C1=CC=CO1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Schepetkin I A , Kirpotina L N , Khlebnikov A I , et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors[J]. Molecular Pharmacology, 2012, 81(6):832-845.
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