JNK-IN-8( JNK-IN-8 | c-Jun N-terminal Kinase Inhibitor XVI )

Catalog No. M11713 CAS No. 1410880-22-6

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Product Name

JNK-IN-8
Note

Research use only, not for human use.
Brief Description

JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively.
Description

JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively; exhibits exceptional selectivity based upon KinomeScan and enzymatic profiling; inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively.
In Vitro

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In Vivo

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Synonyms

JNK-IN-8 | c-Jun N-terminal Kinase Inhibitor XVI
Pathway

MAPK/ERK Signaling
Target

JNK
Recptor

JNK1|JNK2|JNK3|Kit(V559D)|Kit(V559D,T670I)
Research Area

Inflammation/Immunology
Indication

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CAS Number

1410880-22-6
Formula Weight

507.6
Molecular Formula

C29H29N7O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 35 mg/mL
SMILES

CN(C/C=C/C(NC1=CC=CC(C(NC2=CC=C(C(C)=C2)NC3=NC=CC(C4=CN=CC=C4)=N3)=O)=C1)=O)C
Chemical Name

Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-

1. Zhang T, et al. Chem Biol. 2012 Jan 27;19(1):140-54.

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