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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - Heclin

Heclin

CAS No. 890605-54-6

Heclin( Heclin | )

Catalog No. M16428 CAS No. 890605-54-6

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Heclin
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.
  • Description
    A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.
  • In Vitro
    Western Blot Analysis Cell Line:BGC803 and MKN45 cells Concentration:10 μM Incubation Time:48 h Result:Reduced phosphorylation of Akt.
  • In Vivo
    ——
  • Synonyms
    Heclin |
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    890605-54-6
  • Formula Weight
    283.32
  • Molecular Formula
    C17H17NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (352.96 mM)
  • SMILES
    O=C(NC1=CC=C(C(C)=O)C=C1)/C=C/C2=CC=C(CC)O2
  • Chemical Name
    N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41.
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