HM90822( —— )

Catalog No. M36356 CAS No. 1363145-46-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HM90822
Note

Research use only, not for human use.
Brief Description

HM90822 is a novel synthetic apoptotic protein (IAP) antagonist that induces apoptosis in human pancreatic cancer cells through proteasome-dependent degradation of IAPs containing the BIR2/3 structural domain.
Description

HM90822 is a novel synthetic apoptotic protein (IAP) antagonist that induces apoptosis in human pancreatic cancer cells through proteasome-dependent degradation of IAPs containing the BIR2/3 structural domain.HM90822 inhibits the expression of XIAP and cIAP1/2 proteins in HM822-sensitive Panc-1 and BxPC-3 cells, induces ubiquitylation of IAPs and promotes induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

IAP
Recptor

IAP | Apoptosis
Research Area

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Indication

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CAS Number

1363145-46-3
Formula Weight

632.1
Molecular Formula

C30H36ClF2N7O4
Purity

>98% (HPLC)
Solubility

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SMILES

N(C=1C2=C(C=C(OC)C(NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)[C@](C)(C)C)=O)CCC3)=C2)N=CN1)C4=C(F)C(Cl)=C(F)C=C4
Chemical Name

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