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CUDC-427
CAS No. 1446182-94-0
CUDC-427( —— )
Catalog No. M33326 CAS No. 1446182-94-0
CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 112 | In Stock |
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| 2MG | 55 | In Stock |
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| 5MG | 91 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 264 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCUDC-427
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NoteResearch use only, not for human use.
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Brief DescriptionCUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
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DescriptionCUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.
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In VitroGDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 μM (56.5 ng/mL).
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In VivoGDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species.
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Synonyms——
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PathwayApoptosis
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TargetIAP
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RecptorIAP
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Research Area——
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Indication——
Chemical Information
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CAS Number1446182-94-0
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Formula Weight564.7
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Molecular FormulaC29H36N6O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (88.54 mM; Ultrasonic )
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SMILESCN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)Nc1sc(nc1-c1ccccc1)-c1ncco1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13.?
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