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HDAC8-IN-20a
CAS No. 1884231-52-0
HDAC8-IN-20a( HDAC8-IN-20a | HDAC8 IN 20a | HDAC8IN20a | HDAC8 inhibitor-20a )
Catalog No. M12943 CAS No. 1884231-52-0
HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 718 | Get Quote |
|
| 10MG | 981 | Get Quote |
|
| 25MG | 1485 | Get Quote |
|
| 50MG | 2007 | Get Quote |
|
| 100MG | 2637 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameHDAC8-IN-20a
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NoteResearch use only, not for human use.
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Brief DescriptionHDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM.
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DescriptionHDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM; efficiently blocks the activation of growth receptor survival signaling and shifts the cell cycle arrest and differentiation phenotype toward effective cell death of neuroblastoma cell lines combined with crizotinib, efficiently kills neuroblastoma cell lines carrying wildtype ALK, amplified ALK and those carrying the activating ALK F1174L mutation, as well as cells carrying the activating R1275Q mutation.
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In Vitro——
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In Vivo——
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SynonymsHDAC8-IN-20a | HDAC8 IN 20a | HDAC8IN20a | HDAC8 inhibitor-20a
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1884231-52-0
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Formula Weight273.288
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Molecular FormulaC15H15NO4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NO)C1=CC=C(OC)C(OCC2=CC=CC=C2)=C1
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Chemical Name3-(benzyloxy)-N-hydroxy-4-methoxybenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Heimburg T, et al. J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01447.
2. Shen J, et al. Cell Death Differ. 2018 Mar 7. doi: 10.1038/s41418-018-0080-0.
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