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GlyH-101
CAS No. 328541-79-3
GlyH-101( GlyH 101 | GlyH101 )
Catalog No. M14072 CAS No. 328541-79-3
A potent CFTR inhibitor with Ki of 4.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 110 | In Stock |
|
| 25MG | 233 | In Stock |
|
| 50MG | 465 | In Stock |
|
| 100MG | 653 | In Stock |
|
| 200MG | 860 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGlyH-101
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NoteResearch use only, not for human use.
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Brief DescriptionA potent CFTR inhibitor with Ki of 4.3 uM.
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DescriptionA potent CFTR inhibitor with Ki of 4.3 uM; rapidly and reversibly inhibited forskolin-induced hyperpolarization in nasal potential differences in mice; effectively reduces cholera toxin-induced intestinal fluid secretion in a closed-loop model of cholera.
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In VitroGlyH-101 (0-50 μM) shows antiproliferative activity in PCT and PS120 cells.GlyH-101 (0.5, 1, 5, 10 μM) inhibits CFTR-like current in a concentration-dependent manner in PCT cells.GlyH-101 (0.5, 1, 5, 10 μM) inhibits the VSORC current with IC50s of 5.38, 6.26 μM for PS120, PCT cells, respectively. Cell Viability Assay Cell Line:PCT, PS120 cells Concentration:0, 1, 5, 10, 20, 50 μM Incubation Time:24 h Result:Inhibited the cell growth in a dose-dependent manner.
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In VivoGlyH-101 (2.5 μg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse.
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SynonymsGlyH 101 | GlyH101
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PathwayApoptosis
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TargetCFTR
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RecptorCFTR
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number328541-79-3
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Formula Weight493.1487
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Molecular FormulaC19H15Br2N3O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 58 mg/mL
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SMILESO=C(N/N=C/C1=C(O)C(Br)=C(O)C(Br)=C1)CNC2=CC3=CC=CC=C3C=C2
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Chemical NameGlycine, N-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Muanprasat C, et al. J Gen Physiol. 2004 Aug;124(2):125-37.
2. Norimatsu Y, et al. Mol Pharmacol. 2012 Dec;82(6):1042-55.
3. Barman PP, et al. Biochem Biophys Res Commun. 2011 Apr 29;408(1):12-7.
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