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Galanthaminone

CAS No. 510-77-0

Galanthaminone( (-)-Narwedine | Narwedin )

Catalog No. M20683 CAS No. 510-77-0

Galanthaminone is a cholinesterase (AChE) inhibitor?is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Galanthaminone
  • Note
    Research use only, not for human use.
  • Brief Description
    Galanthaminone is a cholinesterase (AChE) inhibitor?is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
  • Description
    Galanthaminone is a cholinesterase (AChE) inhibitor?is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
  • In Vitro
    Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.
  • In Vivo
    Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
  • Synonyms
    (-)-Narwedine | Narwedin
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    AChE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    510-77-0
  • Formula Weight
    285.34
  • Molecular Formula
    C17H19NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (35.05 mM)
  • SMILES
    [H][C@]12CC(=O)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
  • Chemical Name
    (4aS8aS)-4a59101112-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a32-ef][2]benzazepin-6-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Heinrich M Teoh H L . Galanthamine from snowdrop—the development of a modern drug against Alzheimer’s disease from local Caucasian knowledge[J]. Journal of Ethnopharmacology 2004 92(2-3):0-162.
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