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2,3-Dihydrobenzofuran

CAS No. 496-16-2

2,3-Dihydrobenzofuran( 2,3-Dihydrobenzofuran )

Catalog No. M22654 CAS No. 496-16-2

2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara.?Coumaran can be used as a biopesticide.?2,3-dihydrobenzofuran is a member of the class of 1-benzofurans that is the 2,3-dihydroderivative of benzofuran.?It has a role as a metabolite.The in vitro inhibition of acetylcholinesterase was increased with the concentration of Coumaran in the housefly (head and thorax) homogenate.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    2,3-Dihydrobenzofuran
  • Note
    Research use only, not for human use.
  • Brief Description
    2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara.?Coumaran can be used as a biopesticide.?2,3-dihydrobenzofuran is a member of the class of 1-benzofurans that is the 2,3-dihydroderivative of benzofuran.?It has a role as a metabolite.The in vitro inhibition of acetylcholinesterase was increased with the concentration of Coumaran in the housefly (head and thorax) homogenate.
  • Description
    2,3-Dihydrobenzofuran is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara.?Coumaran can be used as a biopesticide.?2,3-dihydrobenzofuran is a member of the class of 1-benzofurans that is the 2,3-dihydroderivative of benzofuran.?It has a role as a metabolite.The in vitro inhibition of acetylcholinesterase was increased with the concentration of Coumaran in the housefly (head and thorax) homogenate. Activity of acetylcholinesterase in insects exposed to LC25, LC50, and LC90 doses of Coumaran was markedly inhibited in dose-dependent studies in the head and thorax of housefly and homogenate of stored grain insect pests. The in vivo enzyme inhibition was dose dependent and correlated with the knockdown effect measured at 45 min of exposure in the fumigation bioassay.
  • In Vitro
    Cell Viability Assay Cell Line:Promastigotes Concentration:0.4, 0.8 and 1.6 μM Incubation Time:48 h Result: Demonstrated a concentration-dependent reduction in infection of macrophages by 7.0, 22.0 and 33.34% for 0.4, 0.8 and 1.6 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    2,3-Dihydrobenzofuran
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    AChE|Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    496-16-2
  • Formula Weight
    120.15
  • Molecular Formula
    C8H8O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 150 mg/mL (1248.44 mM)
  • SMILES
    C1Cc2ccccc2O1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rajashekar Y , Raghavendra A , Bakthavatsalam N . Acetylcholinesterase Inhibition by Biofumigant (Coumaran) from Leaves of Lantana camara in Stored Grain and Household Insect Pests[J]. Biomed Research International, 2014, 2014(187019):187019.
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