GSK812397( GSK 812397 | GSK-812397 )

Catalog No. M16375 CAS No. 878197-98-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

GSK812397
Note

Research use only, not for human use.
Brief Description

GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor.
Description

GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively; does not block CCR5-mediated viral entry in the R5 viral HOS assay (IC50>25 uM); produces a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50=0.34 nM and 2.41 nM, respectively) in cell-based functional assays; demonstrates antiviral activity against a broad range of X4-utilizing strains of HIV-1.
In Vitro

——
In Vivo

——
Synonyms

GSK 812397 | GSK-812397
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

878197-98-9
Formula Weight

420.561
Molecular Formula

C24H32N6O
Purity

>98% (HPLC)
Solubility

——
SMILES

OCC1=C(CN([C@@H]2C3=C(C=CC=N3)CCC2)C)N=C4C=CC=C(N5CCN(C)CC5)N41
Chemical Name

(S)-(2-((methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-5-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanol

1. Jenkinson S, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):817-24.

Calculator

molnova catalog