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BKT-140

CAS No. 664334-36-5

BKT-140( BL-8040 | TF-14016 | 4F-Benzoyl-TN14003 )

Catalog No. M15531 CAS No. 664334-36-5

BKT-140 (TF-14016) is a 14-residue bio stable synthetic peptide; high-affinity CXCR4 antagonist(IC50=1 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BKT-140
  • Note
    Research use only, not for human use.
  • Brief Description
    BKT-140 (TF-14016) is a 14-residue bio stable synthetic peptide; high-affinity CXCR4 antagonist(IC50=1 nM).
  • Description
    BKT-140 (TF-14016) is a 14-residue bio stable synthetic peptide; high-affinity CXCR4 antagonist(IC50=1 nM); inhibits CXCL12-mediated migration of human Jurkat cells and mouse splenocyte in a dose-dependent manner in vitro (IC50=0.65 and 0.54 nM, respectively); ameliorates severity in collagen-induced arthritis in mice.Blood Cancer Phase 2 Clinical.
  • In Vitro
    Motixafortide (BKT140) displays selective toxicity toward AmL and MM cells. Treatment with Motixafortide (BKT140) can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. Motixafortide (BKT140) specifically triggers CXCR4-dependent cell death in leukemia and MM cells. Motixafortide (BKT140) stimulates apoptotic cell death in leukemia and MM cells.
  • In Vivo
    Subcutaneous injections of Motixafortide (BKT140) significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. Tumors from animals treated with Motixafortide (BKT140) are smaller in size and weights, had larger necrotic areas and high apoptotic scores.
  • Synonyms
    BL-8040 | TF-14016 | 4F-Benzoyl-TN14003
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    664334-36-5
  • Formula Weight
    2159.52
  • Molecular Formula
    C97H144FN33O19S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 36 mg/mL
  • SMILES
    C1CC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2C1)CCCCN)CCCCN)CCCNC(=O)N)CC3=CC=C(C=C3)O)NC(=O)C(CC4=CC5=CC=CC=C5C=C4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C6=CC=C(C=C6)F)C(=O)NC(CCCNC(=N)N)C(=O)N)CCCNC(=O)N)CCCNC(=N)N)CC7=CC=C(C=C7)O
  • Chemical Name
    L-Argininamide, N2-(4-fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tamamura H, et al. FEBS Lett. 2004 Jul 2;569(1-3):99-104. 2. Peled A, et al. Clin Cancer Res. 2014 Jan 15;20(2):469-79. 3. Beider K, et al. Exp Hematol. 2011 Mar;39(3):282-92.
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