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GDC046
CAS No. 1258292-64-6
GDC046( —— )
Catalog No. M22623 CAS No. 1258292-64-6
GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | In Stock |
|
| 10MG | 177 | In Stock |
|
| 25MG | 410 | In Stock |
|
| 50MG | 591 | In Stock |
|
| 100MG | 826 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGDC046
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NoteResearch use only, not for human use.
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Brief DescriptionGDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
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DescriptionGDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
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In VitroIn cell-based assays, GDC-046 demonstrates reasonable potency in blocking the IL-12 pathway (IL-12 pSTAT4 EC50=380 nM) while displaying less activity in the EPO (JAK2) pathway (EPO pSTAT5 EC50=1700 nM) and IL-6 (JAK1) pathway (IL-6 pSTAT3 EC50=2000 nM).
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In VivoIn mice, GDC-046 exhibits relatively high clearance (65 mL/min/kg) when dosed intravenously (i.v. 1 mg/kg) and exhibits modest oral exposure (AUC=2.6 μM·h at p.o. 5 mg/kg).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1258292-64-6
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Formula Weight350.2
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Molecular FormulaC16H13Cl2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (178.47 mM)
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SMILESClc1cccc(Cl)c1C(=O)Nc1ccnc(NC(=O)C2CC2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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