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ML224
CAS No. 1338824-21-7
ML224( —— )
Catalog No. M33433 CAS No. 1338824-21-7
ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 135 | In Stock |
|
| 5MG | 117 | In Stock |
|
| 10MG | 187 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML224
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NoteResearch use only, not for human use.
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Brief DescriptionML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.
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DescriptionML224 (NCGC00242364) is a selective TSHR antagonist with an IC50 value of 2.1 μM. ML224 can be used in the study of Graves' disease and other thyroid disorders.
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In VitroCell Viability Assay Cell Line:Human embryonic kidney 293 cells (stably expressing TSHRs, LHRs, or FSHRs) Concentration:0.001-100 μM Incubation Time:20 min Result:Showed the IC50 for stimulation by bovine TSH (1.8 nM) was 2.1 μM.Showed inhibition of LH and FSH stimulation was less than 15% for LH (1 nM) and less than 30% for FSH (1 nM) at 30 μM.
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In VivoAnimal Model:Female BALB/c mice (8 to 13-week-old; ~18.7 g).Dosage:2 mg/mice Administration:Intraperitoneal injection via osmotic pump; single daily for 3 days Result:Lowered the levels of FT4 by 44%, and the levels of TPO and NIS mRNAs by 75% and 83%, respectively.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTSH Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1338824-21-7
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Formula Weight525.59
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Molecular FormulaC31H31N3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (190.26 mM; Ultrasonic )
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SMILESCOc1ccc(cc1COc1c(C)cc(NC(C)=O)cc1C)C1Nc2ccccc2C(=O)N1Cc1ccco1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.?
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