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Fluorobexarotene

CAS No. 1190848-23-7

Fluorobexarotene( —— )

Catalog No. M32926 CAS No. 1190848-23-7

Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 354 In Stock
5MG 440 In Stock
10MG 649 In Stock
25MG 1017 In Stock
50MG 1349 In Stock
100MG 1814 In Stock
200MG Get Quote In Stock
500MG 3618 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Fluorobexarotene
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.
  • Description
    Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Retinoid Receptor
  • Recptor
    Retinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1190848-23-7
  • Formula Weight
    366.47
  • Molecular Formula
    C24H27FO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 36 mg/mL (98.23 mM )
  • SMILES
    CC1=CC2=C(C=C1C(=C)C1=CC(F)=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct?
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