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Feeblin
CAS No. 689270-18-6
Feeblin( —— )
Catalog No. M37085 CAS No. 689270-18-6
Feeblin（IRF5-IN-1） is a protein degradation inducer that specifically blocks pro-inflammatory signaling pathways associated with autoimmune diseases and can be used to study immune system disorders in the class of systemic lupus erythematosus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 55 | In Stock |
|
| 5MG | 80 | In Stock |
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| 10MG | 132 | In Stock |
|
| 25MG | 256 | In Stock |
|
| 50MG | 419 | In Stock |
|
| 100MG | 655 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFeeblin
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NoteResearch use only, not for human use.
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Brief DescriptionFeeblin（IRF5-IN-1） is a protein degradation inducer that specifically blocks pro-inflammatory signaling pathways associated with autoimmune diseases and can be used to study immune system disorders in the class of systemic lupus erythematosus.
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DescriptionIRF5-IN-1 (compound C5) is an IRF5 pathway-specific inhibitor. IRF5-IN-1 significantly reduces IRF5 nuclear translocation without affecting the activation of NF-κB p65. IRF5-IN-1 acts through SLC15A4 to selectively inhibit TLR7/8-induced IRF5 responses in cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number689270-18-6
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Formula Weight431.57
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Molecular FormulaC27H33N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (115.86 mM; Ultrasonic (<80°C)
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SMILESO=C(NCCCN1CCCCC1C)C2=CC(=NC=3C=CC=CC32)C=4C=CC(OCC)=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Andras Boeszoermenyi, et al. A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun. 2023 Oct 20;14(1):6626.?
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