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Endovion

CAS No. 265646-85-3

Endovion( NS3728 )

Catalog No. M24177 CAS No. 265646-85-3

Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Endovion
  • Note
    Research use only, not for human use.
  • Brief Description
    Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
  • Description
    Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
  • In Vitro
    Western Blot Analysis Cell Line:Wild-type, resistant, and transiently transfected A2780 cells.Concentration:10-100 μM.Incubation Time:18 or 4.5 h.Result:Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells.Resulted in an increased LRRC8A protein expression.Significantly reduceed p53 and p21Waf1/Cip1 protein level in A2780WT cells.Cell Proliferation Assay Cell Line:Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines.Concentration:10 μM.Incubation Time:24 h.Result:Resulted in the most pronounced inhibition in all cell lines with 77?±?26 % in Capan-1, 67?±?9 % in AsPC-1, and 54?±?8 % in BxPC-3 cells at +67 mV.
  • In Vivo
    ——
  • Synonyms
    NS3728
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride channel|VRAC/VSOAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    265646-85-3
  • Formula Weight
    495.18
  • Molecular Formula
    C16H9BrF6N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120 mg/mL (242.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Nc(cc(cc1)Br)c1-c1n[nH]nn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.S?rensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against CDDP-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73.
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